Genetic Differences in Sensitivity to Alterations of Mandible Structure Caused by the Teratogen 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent, bioaccumulative and toxic contaminant widely distributed in the environment. Fishes are the most sensitive vertebrates to TCDD, especially during their early developmental stages. TCDD induces various toxic effects including yolk sac edema, craniofacial malformation and neural damage in developing fish embryos. However, the effects of ...

The teratogenic sensitivity to 2,3,7,8-tetrachlorodibenzo-p-dioxin is modified by a locus on mouse chromosome 3.

In an effort to understand how genetics can influence individual sensitivity to environmentally induced disease, we performed a linkage analysis to identify murine loci in addition to the Ahr locus that influence the incidence of cleft palate and hydronephrosis in developing mice exposed to the pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). Administration of 64 microg/kg dioxin to C57B...

Immunological markers among workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

OBJECTIVES To examine the association of immune cell number and function with occupational exposure to substances contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). METHODS A cross sectional medical survey. The exposed participants were employed at two chemical plants between 1951 and 1972 in the manufacture of 2,4,5-trichlorophenate and its derivatives. The reference group consist...

Pathologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals.

The technical chlorophenols and products produced from them, such as the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) have been found to contain chlorodibenzo-pdioxins such as 2,3,7,8-tetrachlorodibenzo-pdioxin (TC-DD). TCDD and other chlorodibenzo-p-dioxins are among the most toxic compounds known, and have been implicated in outbreaks of chloracne among chemical workers (1). Hepatic ...